Database/Antistatic/Glycine
Route-dependent · ISO 16128

Is Glycine natural?

It depends. Glycine has no stereocentre, so cheap chemical synthesis competes strongly with fermentation, unlike most amino acids.

INCI nameGlycine
CAS56-40-6
FormulaC2H5NO2 · 75.07 Da
FunctionAntistatic · Buffering
FeedstockBulk glycine is often made by reacting petrochemical…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Fermentation / protein hydrolysatePlant sugars or hydrolysed protein (soy, gelatin)1.00~35%
Chemical synthesisPetrochemical chloroacetic acid + ammonia, or Strecker synthesis0.00~65%, dominant for bulk supply
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Simplest amino acid; fermentation/hydrolysate (natural) vs chloroacetic acid or Strecker chemical synthesis (petrochemical) give different values
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Bulk glycine is often made by reacting petrochemical chloroacetic acid with ammonia, or via Strecker synthesis. Some supply comes from fermentation or hydrolysed plant/animal protein.

In plain English

The simplest amino acid, used for moisturising and conditioning. It can come from fermented plant sugars or hydrolysed protein, but much of the world's supply is made by chemical synthesis instead.

Natural alternatives with the same function

Structure

2D structure of Glycine

2-aminoacetic acid

PubChem CID 750 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Glycine. PubChem CID 750. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3GLYCINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4GLYCINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=GLYCINE