Database/Fragrance/Thiamine HCl
Mostly petroleum · ISO 16128

Is Thiamine HCl natural?

Mostly not. Commercial vitamin B1 is built by total chemical synthesis; only the chloride counter-ions are natural-origin mineral mass.

INCI nameThiamine HCl
CAS67-03-8
FormulaC12H18Cl2N4OS · 337.3 Da
FunctionFragrance · Skin Conditioning
FeedstockManufactured by total synthesis of the pyrimidine and…

How we scored it

Two Cl- ions (natural, mineral) 71 Da; organic thiamine cation (synthetic) 266 Da petrochemical; 71/337=0.21.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by total synthesis of the pyrimidine and thiazole rings from petrochemical precursors, then salted as the dihydrochloride. No commercially significant fermentation route.

In plain English

Vitamin B1, typically built up from simple chemicals in a lab, in its hydrochloride salt form. Used in fragrance and skin conditioning.

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Structure

2D structure of Thiamine HCl

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

PubChem CID 6202 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Thiamine HCl. PubChem CID 6202. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3THIAMINE HCL. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4THIAMINE HCL. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=THIAMINE%20HCL