Database/Fragrance/Tetramethyl Acetyloctahydronaphthalenes
Mostly natural · ISO 16128

Is Tetramethyl Acetyloctahydronaphthalenes natural?

Mostly. The ten-carbon myrcene part comes from pine turpentine (β-pinene), a natural feedstock; the six-carbon ketone part that carries the acetyl group is made from petrochemical butanone and acetaldehyde.

INCI nameTetramethyl Acetyloctahydronaphthalenes
CAS54464-57-2
FormulaC16H26O · 234.38 Da
FunctionFragrance · Perfuming
FeedstockMyrcene, made by cracking β-pinene from pine turpentine,…

How we scored it

Myrcene C10H16 136.24 Da (from pine turpentine, natural) + 3-methylpent-3-en-2-one C6H10O 98.15 Da (from butanone and acetaldehyde, petrochemical); the Diels–Alder step and ring closure lose no atoms: 136.24/234.38 = 0.58.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

How it’s made

Diels–Alder of myrcene with 3-methylpent-3-en-2-one. The film draws the key step and names the steps after it. Each curved arrow moves one electron pair, and the film ends on the score above.

Where it comes from

Myrcene, made by cracking β-pinene from pine turpentine, is joined to 3-methylpent-3-en-2-one (from petrochemical butanone and acetaldehyde) in a Diels–Alder reaction, and acid then closes a second ring. Myrcene is not made from petroleum at commercial scale.

In plain English

A fragrance ingredient with an amber, woody musk note (also known as Iso E Super) used widely in perfumes. Just over half of it is pine-derived myrcene; the rest is a small ketone made from petrochemicals.

CosIng definition: Tetramethyl Acetyloctahydronaphthalenes is a mixture of isomers that conforms to the following formulae:

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Structure

2D structure of Tetramethyl Acetyloctahydronaphthalenes

1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone

PubChem CID 108242 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Tetramethyl Acetyloctahydronaphthalenes. PubChem CID 108242. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TETRAMETHYL ACETYLOCTAHYDRONAPHTHALENES. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TETRAMETHYL ACETYLOCTAHYDRONAPHTHALENES. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAMETHYL%20ACETYLOCTAHYDRONAPHTHALENES