Database/Not Reported/sh-Polypeptide-105
100% natural origin · ISO 16128

Is sh-Polypeptide-105 natural?

Yes. A protein built wholly from the 20 standard amino acids by E. coli fermentation of sugar and mineral nutrients, with no petrochemical fragment.

INCI namesh-Polypeptide-105
FunctionNot Reported
FeedstockE. coli carrying a synthesised copy of the…

How we scored it

Single polypeptide chain of up to 107 amino-acid residues, plus any disulfide bonds or glycosylation; all natural building blocks, no non-natural groups: 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

E. coli carrying a synthesised copy of the human Growth-Regulated Alpha Protein gene is grown in a fermenter on sugar and ammonium-salt media, then the protein is purified. Other expression hosts would not change the value.

In plain English

A human signalling protein (growth-regulated alpha protein) produced by E. coli bacteria grown in a fermenter, using a copy of the human gene. CosIng reports no specific cosmetic function for it. It is built entirely from the 20 standard amino acids.

CosIng definition: sh-Polypeptide-105 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Growth-Regulated Alpha Protein, used as such or adapted to the production host. It contains a maximum of 107 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-105. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-105. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-105