Database/Perfuming/Nootkatone
Route-dependent · ISO 16128

Is Nootkatone natural?

It depends. Dominant route oxidises natural citrus-derived valencene, retaining its carbons; a minority route is fully synthetic from petrochemicals.

INCI nameNootkatone
CAS4674-50-4
FormulaC15H22O · 218.33 Da
FunctionPerfuming · Fragrance
FeedstockNootkatone is mainly produced by oxidising valencene recovered…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Oxidation/biocatalysis of citrus-derived valenceneValencene from orange peel oil (citrus juice byproduct) or fermentation1.00~70%
Total chemical synthesis from non-terpene petrochemical building blocksPetrochemical intermediates0.00~30%
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Carbon skeleton from valencene (citrus terpene) retained during oxidation to the ketone; minority route builds the ring system synthetically.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Nootkatone is mainly produced by oxidising valencene recovered as a byproduct of orange/grapefruit juice processing, or increasingly via fermentation. A smaller share, especially for insect-repellent grades, is built by total synthesis from non-terpene petrochemical feedstocks.

In plain English

A grapefruit-scented compound usually made by chemically converting an orange-peel-oil terpene, sometimes made by fermentation, occasionally built up from scratch synthetically. It smells and tastes like grapefruit.

CosIng definition: Nootkatone is the organic compound that conforms to the formula

Natural alternatives with the same function

Structure

2D structure of Nootkatone

(4R,4aS,6R)-4,4a-dimethyl-6-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one

PubChem CID 1268142 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Nootkatone. PubChem CID 1268142. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3NOOTKATONE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4NOOTKATONE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=NOOTKATONE