Database/Not Reported/Ketoconazole
100% petroleum · ISO 16128

Is Ketoconazole natural?

No. Wholly synthetic antifungal built from petrochemical dichlorophenyl, imidazole and piperazine precursors; no natural-origin fragment.

INCI nameKetoconazole
CAS65277-42-1
FormulaC26H28Cl2N4O4 · 531.4 Da
FunctionNot Reported
FeedstockProduced by multi-step organic synthesis from petrochemical aromatic…

How we scored it

Fully synthetic dioxolane-imidazole-piperazine molecule; every fragment from petrochemical synthesis → 0.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by multi-step organic synthesis from petrochemical aromatic and heterocyclic intermediates. No natural or fermentation route exists for this molecule.

In plain English

A synthetic antifungal ingredient sometimes used in anti-dandruff products. It is made entirely through laboratory chemical synthesis from petroleum-derived starting materials.

CosIng definition: Ketoconazole is the heterocyclic compound that conforms to the formula

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Structure

2D structure of Ketoconazole

1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

PubChem CID 47576 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Ketoconazole. PubChem CID 47576. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3KETOCONAZOLE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4KETOCONAZOLE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=KETOCONAZOLE