Database/Fragrance/Hydroxypropyl Cyclodextrin
Mostly natural · ISO 16128

Is Hydroxypropyl Cyclodextrin natural?

Mostly. Beta-cyclodextrin ring is enzymatically made from starch (natural); hydroxypropyl ether groups come from petrochemical propylene oxide.

INCI nameHydroxypropyl Cyclodextrin
CAS128446-33-3
FunctionFragrance · Skin Conditioning
FeedstockHydroxypropyl Cyclodextrin is made by enzymatically converting starch…

How we scored it

PubChem formula (C39H66O31) matches alpha-cyclodextrin+1 HP group, contradicting the named beta-CD — using description: beta-CD C42H70O35 (1135.0 Da, starch, natural) + ~4.5 hydroxypropyl (MS4.5, 261.4 Da, propylene oxide) = 1396.4 Da; 1135.0/1396.4=0.81
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Hydroxypropyl Cyclodextrin is made by enzymatically converting starch into beta-cyclodextrin, then reacting it with petrochemical propylene oxide to add hydroxypropyl ether groups. Commercial degree of substitution varies by supplier grade, typically MS 4-5.

In plain English

A starch-derived ring molecule used to trap and stabilize fragrance or active ingredients, modified with a small amount of petrochemical propylene oxide.

CosIng definition: .beta.-Cyclodextrin, 2-hydroxypropyl ethers

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2HYDROXYPROPYL CYCLODEXTRIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3HYDROXYPROPYL CYCLODEXTRIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=HYDROXYPROPYL%20CYCLODEXTRIN