Database/Perfuming/Gamma-Dodecalactone
Route-dependent · ISO 16128

Is Gamma-Dodecalactone natural?

It depends. Natural route traces every carbon to castor-oil ricinoleic acid via yeast fermentation; synthetic route traces to petrochemical oxo-aldehyde and acrylate feedstocks.

INCI nameGamma-Dodecalactone
CAS2305-05-7
FormulaC12H22O2 · 198.30 Da
FunctionPerfuming
FeedstockCan be produced by yeast (Yarrowia lipolytica) fermentation…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Petrochemical synthesisoxo-process octyl aldehyde + acrylate-type unit, lactonised0.00~60%
Fermentationricinoleic acid (castor oil) beta-oxidised by Yarrowia lipolytica yeast, lactonised1.00~40%
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Natural route: Yarrowia fermentation of castor-oil ricinoleic acid, lactonised, retains every carbon, 1.0. Synthetic route: petrochemical oxo-aldehyde + acrylate-type unit, lactonised, 0.0. Synthetic assumed larger by volume.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Can be produced by yeast (Yarrowia lipolytica) fermentation of castor-oil-derived ricinoleic acid, trimmed and lactonised with every carbon traceable to castor oil. Alternatively synthesised from petrochemical aldehydes via oxo-synthesis and lactonisation; the synthetic route is assumed larger-volume.

In plain English

A fruity, creamy-scented fragrance ingredient. It can be made naturally through fermentation of castor-oil-derived fatty acids, or synthesised from petrochemical building blocks; both routes exist commercially.

Natural alternatives with the same function

Structure

2D structure of Gamma-Dodecalactone

5-octyloxolan-2-one

PubChem CID 16821 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Gamma-Dodecalactone. PubChem CID 16821. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3GAMMA-DODECALACTONE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4GAMMA-DODECALACTONE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=GAMMA-DODECALACTONE