Database/Anti-Seborrheic/Clotrimazole
100% petroleum · ISO 16128

Is Clotrimazole natural?

No. Every fragment (chlorophenyl, two phenyl rings, imidazole) originates from petrochemical benzene/toluene and ammonia-derived synthesis; nothing is natural-origin.

INCI nameClotrimazole
CAS23593-75-1
FormulaC22H17ClN2 · 344.8 Da
FunctionAnti-Seborrheic · Antimicrobial
FeedstockManufactured entirely by multistep organic synthesis from chlorobenzene,…

How we scored it

Wholly synthetic imidazole antifungal built from chlorophenyl, diphenylmethyl and imidazole petrochemical precursors; no natural fragment present anywhere in the molecule.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured entirely by multistep organic synthesis from chlorobenzene, benzophenone and imidazole precursors. No natural or biosynthetic route is used commercially.

In plain English

A synthetic antifungal and antimicrobial active used in anti-dandruff and medicated products. Made entirely by chemical synthesis from petrochemical starting materials; not found in nature.

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Structure

2D structure of Clotrimazole

1-[(2-chlorophenyl)-diphenylmethyl]imidazole

PubChem CID 2812 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Clotrimazole. PubChem CID 2812. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CLOTRIMAZOLE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CLOTRIMAZOLE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CLOTRIMAZOLE