Database/Colorant/CI 45430
Mostly petroleum · ISO 16128

Is CI 45430 natural?

Mostly not. Only the sodium counter-ion is unambiguously natural; the iodinated fluorescein core is built via petrochemical synthesis, so iodine is not credited as natural.

INCI nameCI 45430
CAS16423-68-0
FunctionColorant
FeedstockErythrosine is manufactured by iodinating a synthetic fluorescein…

How we scored it

Erythrosine disodium salt, C20H6I4Na2O5 (approx 880Da): Na2 (46Da, natural) counted; iodine (508Da) treated conservatively as part of the synthetic halogenation, not a listed mineral counter-ion. Natural approx 46/880 approx 0.05.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Erythrosine is manufactured by iodinating a synthetic fluorescein base made from petrochemical resorcinol and phthalic anhydride, then neutralizing it to the sodium salt. Mined iodine is not counted as natural since it is a reagent in a fully synthetic process.

In plain English

A bright pink-red synthetic dye (erythrosine) used to color cosmetics. Made by iodinating a synthetic aromatic dye base; sodium contributes a small mineral-derived portion of its mass.

CosIng definition: CI 45430 is classed chemically as a xanthene colour. It conforms to the formula:

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Structure

2D structure of CI 45430

PubChem CID 3259 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2CI 45430. PubChem CID 3259. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CI 45430. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CI 45430. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CI%2045430