Database/Colorant/CI 45370
100% petroleum · ISO 16128

Is CI 45370 natural?

No. Synthetic brominated xanthene colorant from petrochemical aromatic feedstocks, resorcinol and phthalic anhydride; no natural fragments.

INCI nameCI 45370
CAS4372-02-5
FormulaC20H8Br2Na2O5 · 534.1 Da
FunctionColorant
FeedstockSynthesised by condensing resorcinol with phthalic anhydride to…

How we scored it

Dibromofluorescein disodium salt (xanthene dye); made from resorcinol/phthalic anhydride then brominated, all petrochemical aromatics. Entirely synthetic.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Synthesised by condensing resorcinol with phthalic anhydride to form fluorescein, then brominating and converting to the disodium salt, all from petroleum-based benzene chemistry. No natural production route exists.

In plain English

An orange-red synthetic dye used to colour cosmetic and personal care products. Manufactured from petrochemical aromatic building blocks and bromine.

CosIng definition: CI 45370 is classed chemically as a xanthene colour. It conforms to the formula:

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Structure

2D structure of CI 45370

disodium;4',5'-dibromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

PubChem CID 20388 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2CI 45370. PubChem CID 20388. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CI 45370. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CI 45370. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CI%2045370