Database/Antioxidant/Zinc Pyridoxal 5-Phosphate
Mostly petroleum · ISO 16128

Is Zinc Pyridoxal 5-Phosphate natural?

Mostly not. Zinc and phosphate are mineral ions, while the pyridoxal ring comes from synthetic vitamin B6 (petrochemical building blocks), as with pyridoxine esters under this site's convention.

INCI nameZinc Pyridoxal 5-Phosphate
FormulaC8H8NO6PZn · 310.5 Da
FunctionAntioxidant · Skin Conditioning
FeedstockVitamin B6 is made by chemical synthesis; pyridoxal…

How we scored it

Zn 65.4 + phosphate PO3 79.0 = 144.4 Da natural/mineral; pyridoxal C8H8NO3 166.2 Da petrochemical (synthetic vitamin B6). 144.4 / 310.5 = 0.46.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Vitamin B6 is made by chemical synthesis; pyridoxal is obtained by oxidising pyridoxine, phosphorylated with phosphoric acid, and reacted with a zinc salt. Fermentation-derived vitamin B6 is not commercially significant.

In plain English

The zinc salt of pyridoxal 5-phosphate, the active form of vitamin B6, used as an antioxidant and skin-conditioning ingredient. The zinc and phosphate are minerals, while the vitamin B6 ring is made by chemical synthesis.

CosIng definition: Zinc Pyridoxal 5-Phosphate is the zinc salt of Pyridoxal 5-Phosphate

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Structure

2D structure of Zinc Pyridoxal 5-Phosphate

zinc (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl phosphate

PubChem CID 76968358 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Zinc Pyridoxal 5-Phosphate. PubChem CID 76968358. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ZINC PYRIDOXAL 5-PHOSPHATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ZINC PYRIDOXAL 5-PHOSPHATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ZINC%20PYRIDOXAL%205-PHOSPHATE