Database/Skin Conditioning/Xanthohumol
100% natural origin · ISO 16128

Is Xanthohumol natural?

Yes. Isolated from hop (Humulus lupulus) flower extract; no significant commercial petrochemical synthesis route.

INCI nameXanthohumol
CAS6754-58-1
FormulaC21H22O5 · 354.4 Da
FunctionSkin Conditioning
FeedstockExtracted and purified from hop cones (Humulus lupulus),…

How we scored it

Prenylated chalcone flavonoid naturally occurring in hops; commercially obtained by extraction from hop cones, so the whole molecule is natural (n=1).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Extracted and purified from hop cones (Humulus lupulus), a byproduct of the brewing industry. Laboratory total synthesis exists but is not the commercial route.

In plain English

A natural compound from hops used to condition skin. It's extracted from hop flowers rather than made synthetically.

Structure

2D structure of Xanthohumol

(E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

PubChem CID 639665 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Xanthohumol. PubChem CID 639665. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3XANTHOHUMOL. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4XANTHOHUMOL. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=XANTHOHUMOL