Database/Skin Conditioning/Tripeptide-35
100% natural origin · ISO 16128

Is Tripeptide-35 natural?

Yes. Glutamic acid, cysteine and glycine are fermentation or hydrolysate amino acids, and peptide coupling reagents and protecting groups leave no mass.

INCI nameTripeptide-35
FunctionSkin Conditioning
FeedstockFermentation-derived amino acids (L-cysteine also from keratin hydrolysate)…

How we scored it

Glu-Cys-Gly tripeptide C10H17N3O6S ~307 Da; each residue is a natural amino acid (cysteine S is amino-acid sulfur, not a petrochemical thiol); no caps; 307 / 307 = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Fermentation-derived amino acids (L-cysteine also from keratin hydrolysate) are coupled by peptide synthesis into the tripeptide. No alternative route is significant.

In plain English

A short chain of three amino acids (glutamic acid, cysteine and glycine) used to condition skin. It is assembled in a lab from individual amino acids, which are normally produced by fermentation or from protein hydrolysates.

CosIng definition: Tripeptide-35 is the synthetic peptide consisting of cysteine, glutamic acid and glycine

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2TRIPEPTIDE-35. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3TRIPEPTIDE-35. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TRIPEPTIDE-35