Database/Skin Conditioning/Trifluoroacetyl Tripeptide-2
Mostly natural · ISO 16128

Is Trifluoroacetyl Tripeptide-2 natural?

Mostly. Amino-acid tripeptide backbone is natural; the trifluoroacetyl cap is a fluorinated synthetic group with no natural source.

INCI nameTrifluoroacetyl Tripeptide-2
CAS64577-63-5
FormulaC21H28F3N3O6 · 475.5 Da
FunctionSkin Conditioning · Skin Protecting
FeedstockBuilt from amino acids joined into a tripeptide,…

How we scored it

Peptide backbone C19H29N3O5 (379.5) natural; trifluoroacetyl cap net addition (96.0) petrochemical/fluorinated; 379.5/475.5=0.80.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built from amino acids joined into a tripeptide, then capped with a trifluoroacetyl group from trifluoroacetic acid. The peptide backbone is natural; the fluorinated cap is entirely synthetic.

In plain English

A short lab-made peptide capped with a fluorinated (trifluoroacetyl) group, used in skin-conditioning and skin-protecting formulas.

CosIng definition: Trifluoroacetyl Tripeptide-2 is the reaction product of trifluoroacetic acid and Tripeptide-2

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Structure

2D structure of Trifluoroacetyl Tripeptide-2

(2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]amino]propanoyl]amino]-3-methylbutanoic acid

PubChem CID 40785040 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Trifluoroacetyl Tripeptide-2. PubChem CID 40785040. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TRIFLUOROACETYL TRIPEPTIDE-2. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TRIFLUOROACETYL TRIPEPTIDE-2. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TRIFLUOROACETYL%20TRIPEPTIDE-2