Database/Emollient/Theanine
Route-dependent · ISO 16128

Is Theanine natural?

It depends. Two commercially significant routes give different answers, so a single number would be misleading. Most bulk theanine is made by reacting fermentation-derived glutamine with synthetic ethylamine, which leaves the ethylamine fragment petrochemical; tea-leaf extract and whole-cell fermentation give a fully natural molecule.

INCI nameTheanine
CAS3081-61-6
FormulaC7H14N2O3 · 174.20 Da
FunctionEmollient · Humectant
FeedstockThe main route reacts fermentation-derived glutamine or glutamic…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Enzymatic synthesis from fermentation glutamine plus ethylamineglucose-fermentation glutamine + synthetic ethylamine0.75majority of bulk supply44.08 Da of the 174.20 Da molecule comes from ethylamine
Tea-leaf extraction or whole-cell fermentationgreen tea leaf, or microbial fermentation of plant sugars1.00minority, natural-labelled grades
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Theanine is C7H14N2O3, 174.20 Da. On the enzymatic route the glutamate-derived core (C5H8NO3, 130.12 Da) is natural and the fragment contributed by ethylamine (N plus C2H6, 44.08 Da) is petrochemical: 130.12/174.20 = 0.75. Theanine extracted from tea leaf or made by whole-cell fermentation keeps every atom natural, 174.20/174.20 = 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

The main route reacts fermentation-derived glutamine or glutamic acid with ethylamine, a small synthetic amine, using a glutaminase enzyme. Smaller volumes are extracted from green tea leaf or produced by direct microbial fermentation, both of which keep every atom natural origin.

In plain English

An amino-acid-like compound found naturally in tea leaves, commercially made by joining a fermentation-derived building block to a small synthetic component. Used to condition skin and hold in moisture.

Natural alternatives with the same function

Structure

2D structure of Theanine

(2S)-2-amino-5-(ethylamino)-5-oxopentanoic acid

PubChem CID 439378 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Theanine. PubChem CID 439378. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3THEANINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4THEANINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=THEANINE