Database/Skin Conditioning/Tetrapeptide-5
100% natural origin · ISO 16128

Is Tetrapeptide-5 natural?

Yes. Every unit is an amino acid, and peptides built from amino acids count as natural origin here even where one of them, such as beta-alanine, is usually made by chemical synthesis.

INCI nameTetrapeptide-5
CAS883220-97-1
FormulaC18H26N8O6 · 450.4 Da
FunctionSkin Conditioning
FeedstockHistidine and serine come from fermentation or protein…

How we scored it

C18H26N8O6, 450.4 Da = beta-Ala-His-Ser-His. Peptides built from amino acids are natural origin on this site, beta-alanine included (as Anserine): 450 / 450 = 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Histidine and serine come from fermentation or protein hydrolysis; beta-alanine is mostly made from acrylonitrile or acrylic acid and ammonia, with a smaller fermentation-based route. The four units are joined by peptide synthesis.

In plain English

A chain of four amino acid units (beta-alanine, histidine, serine and histidine) used to condition skin. Histidine and serine come from fermentation or plant protein, while beta-alanine is normally made by a chemical route. The units are linked together in a factory.

CosIng definition: Tetrapeptide-5 is a synthetic peptide containing alanine, histidine and serine residues

Structure

2D structure of Tetrapeptide-5

(2S)-2-[[(2S)-2-[[(2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid

PubChem CID 71587844 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Tetrapeptide-5. PubChem CID 71587844. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TETRAPEPTIDE-5. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TETRAPEPTIDE-5. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAPEPTIDE-5