Database/Skin Conditioning/Tetrapeptide-4
100% natural origin · ISO 16128

Is Tetrapeptide-4 natural?

Yes. Built from natural fermentation-derived amino acids (glycine, glutamic acid, proline); synthesis reagents leave no mass.

INCI nameTetrapeptide-4
CAS960608-16-6
FormulaC14H22N4O7 · 358.35 Da
FunctionSkin Conditioning
FeedstockChemically assembled from the natural amino acids glycine,…

How we scored it

Peptide of glycine, glutamic acid and proline residues; peptides from natural amino acids are 1.0 regardless of chemical synthesis method.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Chemically assembled from the natural amino acids glycine, glutamic acid and proline. Single synthesis route; no petrochemical building blocks involved.

In plain English

A small peptide used to help condition skin, built from the same natural amino acids found in proteins throughout the body.

CosIng definition: Tetrapeptide-4 is a synthetic peptide containing glysine, glutamic acid and proline residues

Structure

2D structure of Tetrapeptide-4

(4S)-4-[(2-aminoacetyl)amino]-5-[(2S)-2-(carboxymethylcarbamoyl)pyrrolidin-1-yl]-5-oxopentanoic acid

PubChem CID 42630676 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Tetrapeptide-4. PubChem CID 42630676. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TETRAPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TETRAPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAPEPTIDE-4