Database/Skin Conditioning/Tetrapeptide-21
100% natural origin · ISO 16128

Is Tetrapeptide-21 natural?

Yes. All constituent amino acids are fermentation or hydrolysate-derived; chemical coupling reagents contribute no mass to the final peptide.

INCI nameTetrapeptide-21
CAS960608-17-7
FormulaC15H27N5O7 · 389.40 Da
FunctionSkin Conditioning
FeedstockChemically synthesised by coupling glutamic acid, glycine and…

How we scored it

Synthetic peptide of natural amino acids, glutamic acid, glycine, lysine; coupling reagents leave no mass. 100% natural.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Chemically synthesised by coupling glutamic acid, glycine and lysine into a four-unit peptide chain. The amino acid building blocks are natural-origin; synthesis reagents leave no mass in the product.

In plain English

A small peptide built from three natural amino acids. Used in skincare formulas for skin-conditioning purposes.

CosIng definition: Tetrapeptide-21 is the synthetic peptide consisting of glutamic acid, glycine and lysine

Structure

2D structure of Tetrapeptide-21

(4S)-4-[(2-aminoacetyl)amino]-5-[[(2S)-6-amino-1-(carboxymethylamino)-1-oxohexan-2-yl]amino]-5-oxopentanoic acid

PubChem CID 42630677 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Tetrapeptide-21. PubChem CID 42630677. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TETRAPEPTIDE-21. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TETRAPEPTIDE-21. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAPEPTIDE-21