Database/Skin Conditioning/Tetrapeptide-16
100% natural origin · ISO 16128

Is Tetrapeptide-16 natural?

Yes. Built solely from fermentation-derived amino acids (glutamic acid, glutamine, lysine, proline); synthesis reagents contribute no atoms.

INCI nameTetrapeptide-16
FunctionSkin Conditioning
FeedstockManufactured by solid-phase peptide synthesis from fermentation-derived amino…

How we scored it

Peptide of Glu+Gln+Lys+Pro only; amino acids are fermentation/hydrolysate products; coupling reagents leave no mass. 100% natural-origin mass.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by solid-phase peptide synthesis from fermentation-derived amino acids. No alternative route is commercially significant.

In plain English

A lab-made chain of four amino acids used to condition skin. The amino-acid building blocks come from fermentation, so it counts as fully natural-origin even though it is assembled synthetically.

CosIng definition: Tetrapeptide-16 is the synthetic peptide consisting of glutamic acid, glutamine, lysine and proline

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2TETRAPEPTIDE-16. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3TETRAPEPTIDE-16. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAPEPTIDE-16