Database/Skin Conditioning/Tetrapeptide-1
100% natural origin · ISO 16128

Is Tetrapeptide-1 natural?

Yes. Leucine, proline, threonine and valine are fermentation or protein-hydrolysate amino acids; coupling reagents and protecting groups leave no mass.

INCI nameTetrapeptide-1
CAS1632354-04-1
FormulaC20H36N4O6 · 428.5 Da
FunctionSkin Conditioning
FeedstockAmino acids from sugar fermentation or protein hydrolysis…

How we scored it

C20H36N4O6, 428.5 Da = Leu + Pro + Thr + Val - 3 H2O (formula checked). No acyl cap: all atoms from amino acids, 428.5 / 428.5 = 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Amino acids from sugar fermentation or protein hydrolysis are joined by peptide synthesis. No alternative route changes the value.

In plain English

A chain of four amino acids (leucine, proline, threonine and valine) used to condition skin. The amino acids come from fermentation or plant protein and are linked together in a factory.

CosIng definition: Tetrapeptide-1 is a synthetic peptide containing leucine, proline, threonine, and valine

Structure

2D structure of Tetrapeptide-1

(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoic acid

PubChem CID 169450584 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Tetrapeptide-1. PubChem CID 169450584. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3TETRAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4TETRAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=TETRAPEPTIDE-1