Database/Skin Protecting/Synephrine
Route-dependent · ISO 16128

Is Synephrine natural?

It depends. Occurs in bitter-orange fruit but is often made synthetically for cost and purity; which route dominates cosmetic-grade supply is unclear.

INCI nameSynephrine
CAS94-07-5
FormulaC9H13NO2 · 167.20 Da
FunctionSkin Protecting
FeedstockCan be extracted from unripe Citrus aurantium (bitter…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
citrus extractionCitrus aurantium (bitter orange) fruit1.00minority, unconfirmed
chemical synthesispetrochemical phenolic ketone via reductive amination0.00majority, unconfirmed
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

C9H13NO2 phenethylamine; whole-molecule route choice, not a fragment split. Extraction keeps atoms plant-derived; synthesis from phenolic-ketone precursors makes atoms petrochemical. Headline shows the best route (1.00), as for every route-dependent entry on the site.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Can be extracted from unripe Citrus aurantium (bitter orange) fruit, or synthesised from petrochemical phenolic-ketone precursors by reductive amination. The dominant route for cosmetic-grade material could not be confirmed.

In plain English

A compound related to ones found in bitter orange, used here to help protect skin. It may be extracted from the fruit or made synthetically; we could not confirm which source applies.

CosIng definition: Synephrine is the organic compound

Natural alternatives with the same function

Structure

2D structure of Synephrine

4-[1-hydroxy-2-(methylamino)ethyl]phenol

PubChem CID 7172 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Synephrine. PubChem CID 7172. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3SYNEPHRINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4SYNEPHRINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SYNEPHRINE