Database/Skin Conditioning/Sucralose
Mostly natural · ISO 16128

Is Sucralose natural?

Mostly. The carbon/hydrogen/oxygen skeleton is unmodified sucrose; the three substituted chlorine atoms are counted as a synthetic modification, per this site's chlorinated-fragment convention.

INCI nameSucralose
CAS56038-13-2
FormulaC12H19Cl3O8 · 397.6 Da
FunctionSkin Conditioning
FeedstockMade by selectively chlorinating food-grade sucrose (cane or…

How we scored it

Sucrose skeleton after loss of 3 OH (C12H19O8, 291.3 Da, natural) + 3 Cl from chlorination (106.4 Da, treated as synthetic) = 397.6 Da; 291.3/397.6 = 0.73.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by selectively chlorinating food-grade sucrose (cane or beet sugar) at three hydroxyl positions. The sugar backbone is agricultural, but the trichlorination is an industrial organochlorine step with no natural analogue.

In plain English

An intensely sweet ingredient made by replacing three hydroxyl groups on ordinary sugar with chlorine atoms. The sugar backbone comes from plants; the chlorination step is a synthetic chemical process.

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Structure

2D structure of Sucralose

(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol

PubChem CID 71485 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Sucralose. PubChem CID 71485. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3SUCRALOSE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4SUCRALOSE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SUCRALOSE