How we scored it
Protease enzyme (protein) produced by Bacillus fermentation; amino-acid-based proteins are natural origin. 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermenting Bacillus species and purifying the secreted enzyme. Microbial fermentation is the sole commercial production route for cosmetic-grade subtilisin.
In plain English
An enzyme produced by fermenting bacteria, used to gently exfoliate skin by helping break down surface proteins, made through a natural fermentation process.
CosIng definition: Enzymes, subtilisin
Structure
3-[3,9-bis(2-amino-2-oxoethyl)-16-(1-hydroxyethyl)-19-(hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-13-octyl-2,5,8,11,15,18,21,24-octaoxo-1,4,7,10,14,17,20,23-octazabicyclo[23.3.0]octacosan-22-yl]propanoic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2Subtilisin. PubChem CID 57078918. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3SUBTILISIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4SUBTILISIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SUBTILISIN