Database/Skin Conditioning/Sodium Glycinate
Route-dependent · ISO 16128

Is Sodium Glycinate natural?

It depends. Sodium salt of glycine. The sodium is always natural; the glycine can come from natural sources or chemical synthesis, so the score is route-dependent, as for Glycine.

INCI nameSodium Glycinate
CAS6000-44-8
FormulaC2H4NNaO2 · 97.05 Da
FunctionSkin Conditioning
FeedstockGlycine neutralised with sodium hydroxide.

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
natural glycinefermentation or protein-hydrolysate glycine neutralised with sodium hydroxide1.00All natural.
synthetic glycineStrecker or chloroacetic-acid glycine neutralised with sodium hydroxide0.24Only sodium counts: 23.0/97.0 = 0.24.
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

C2H4NNaO2 97.0 Da: sodium 23.0 Da is mineral in both routes; the glycinate anion is natural from fermentation glycine (NOI 1.00) and petrochemical from chemically synthesised glycine (0.24). Headline shows the natural route.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Glycine neutralised with sodium hydroxide.

In plain English

The sodium salt of glycine, a small amino acid, used to condition skin. Most commercial supply is made by chemical synthesis rather than fermentation, unlike many other amino acids.

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Structure

2D structure of Sodium Glycinate

sodium 2-aminoacetate

PubChem CID 4684308 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Sodium Glycinate. PubChem CID 4684308. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3SODIUM GLYCINATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4SODIUM GLYCINATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SODIUM%20GLYCINATE