Database/Skin Conditioning/Silybin
100% natural origin · ISO 16128

Is Silybin natural?

Yes. Plant-derived flavonolignan isolated from milk thistle seed; no commercially significant synthetic route.

INCI nameSilybin
CAS22888-70-6
FormulaC25H22O10 · 482.4 Da
FunctionSkin Conditioning
FeedstockIsolated by extraction and purification from the seeds…

How we scored it

Flavonolignan extracted from milk thistle seed; commercial source is extraction, total synthesis not economical = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Isolated by extraction and purification from the seeds of milk thistle (Silybum marianum). This is the standard commercial production method; chemical synthesis is not used industrially.

In plain English

A natural antioxidant extracted from milk thistle seeds, used in skincare to help condition and protect skin. Comes directly from the milk thistle plant.

Structure

2D structure of Silybin

(2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

PubChem CID 31553 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Silybin. PubChem CID 31553. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3SILYBIN. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4SILYBIN. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SILYBIN