How we scored it
Tripeptide of serine and tyrosine, assembled from amino acids; protecting groups and coupling reagents leave no mass, so all atoms are natural: 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Dominant route: solid-phase chemical synthesis from fermentation-derived protected amino acids. No alternative route is commercially significant.
In plain English
A three-amino-acid peptide of serine and tyrosine, made to match a short stretch of the human hormone alpha-melanotropin. It is used to condition skin and is built in the lab from amino acids.
CosIng definition: sh-Tripeptide-5 is a single chain human peptide produced synthetically to be identical to a portion of the protein, Melanotropin Alpha which contains a maximum of 267 amino acids. sh-Tripeptide-5 contains 3 amino acids consisting of serine and tyrosine.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-TRIPEPTIDE-5. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-TRIPEPTIDE-5. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-TRIPEPTIDE-5