Database/Humectant/sh-Polypeptide-8
100% natural origin · ISO 16128

Is sh-Polypeptide-8 natural?

Yes. Built entirely from fermentation-derived amino acids in engineered E. coli; no synthetic fragments added.

INCI namesh-Polypeptide-8
FunctionHumectant · Skin Conditioning
FeedstockProduced by fermenting E. coli engineered with a…

How we scored it

Recombinant protein from the 20 standard amino acids via fermentation; no petrochemical mass.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting E. coli engineered with a synthetic copy of the human PDGF gene; amino acids are the sole feedstock. No alternative commercial route exists.

In plain English

A lab-grown protein made by fermenting engineered bacteria carrying a copy of the human PDGF gene. Used in skincare as a humectant and skin-conditioning ingredient.

CosIng definition: sh-Polypeptide-8 is a single chain synthetic human peptide, produced by fermentation in E.Coli. The starting gene is a synthesized copy of the human gene which codes for Platelet Derived Growth Factor used as such or adapted to the production host. It contains a maximum of 211 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-8. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-8. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-8