How we scored it
Chemically synthesised peptide assembled from standard amino acids = 1.0 (amino acids are fermentation-derived; coupling chemistry leaves no mass).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Chemically assembled from the 20 standard amino acids to replicate a human TGF-beta2-identical sequence. Protecting groups and coupling agents used in synthesis leave no mass in the final product.
In plain English
A synthetic copy of a human growth-factor protein (TGF-beta2), chemically assembled from amino acids. Used to condition skin in advanced skincare.
CosIng definition: sh-Polypeptide-76 is a synthetic peptide chemically produced to be identical to the human protein or piece of human protein, Transforming Growth Factor Beta-2. It contains a maximum of 414 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-76. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-76. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-76