Database/Humectant/sh-Polypeptide-6
100% natural origin · ISO 16128

Is sh-Polypeptide-6 natural?

Yes. Built solely from natural amino acids via E. coli fermentation; folding and glycosylation add no non-natural mass.

INCI namesh-Polypeptide-6
FunctionHumectant · Skin Conditioning
FeedstockProduced by fermenting engineered E. coli expressing a…

How we scored it

Recombinant protein assembled from the 20 standard amino acids (fermentation-origin); no petrochemical fragments in the final peptide.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting engineered E. coli expressing a synthetic copy of the human IL-10 gene; amino acids are the sole feedstock. No alternative commercial route exists.

In plain English

A lab-grown protein made by fermenting engineered bacteria that carry a copy of a human gene, designed to mimic interleukin-10 activity. Used as a humectant and skin-conditioning ingredient in serums and moisturizers.

CosIng definition: sh-Polypeptide-6 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Interleukin 10 used as such or adapted to the production host. It contains a maximum of 160 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-6. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-6. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-6