Database/Skin Conditioning/sh-Polypeptide-50
100% natural origin · ISO 16128

Is sh-Polypeptide-50 natural?

Yes. Recombinant tropoelastin-sequence protein assembled from fermentation-derived amino acids in engineered E. coli; production machinery leaves no mass in product.

INCI namesh-Polypeptide-50
FunctionSkin Conditioning
FeedstockProduced by fermenting genetically engineered E. coli expressing…

How we scored it

Peptide/protein built from standard amino acids via fermentation = 1.0, independent of chain length (786 residues).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli expressing a human tropoelastin-identical sequence built from standard amino acids. No petrochemical alternative route is used commercially.

In plain English

A lab-made copy of human tropoelastin, a skin-elasticity protein, produced by fermenting engineered bacteria. Used to condition skin in anti-aging products.

CosIng definition: sh-Polypeptide-50 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Tropoelastin used such or adapted to the production host. It contains a maximum of 786 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-50. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-50. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-50