Database/Skin Conditioning/sh-Polypeptide-46
100% natural origin · ISO 16128

Is sh-Polypeptide-46 natural?

Yes. Recombinant protein assembled entirely from fermentation-derived amino acids in engineered E. coli; coupling/expression machinery leaves no mass in the product.

INCI namesh-Polypeptide-46
FunctionSkin Conditioning
FeedstockProduced by fermenting genetically engineered E. coli that…

How we scored it

Peptide built from the 20 standard amino acids via fermentation; amino acids are fermentation-derived, so the chain is 1.0 regardless of chain length.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli that express a human-identical interferon alpha-2 sequence, built from standard amino acids. No petrochemical alternative route is used commercially.

In plain English

A lab-made copy of a human signalling protein (interferon alpha-2), produced by fermenting genetically engineered bacteria. Used for skin conditioning in advanced formulas.

CosIng definition: sh-Polypeptide-46 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Interferon Alpha 2. It contains a maximum of 188 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-46. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-46. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-46