Database/Antioxidant/sh-Polypeptide-4
100% natural origin · ISO 16128

Is sh-Polypeptide-4 natural?

Yes. Ribosomally expressed protein made of the 20 standard amino acids via microbial fermentation; a fermentation product by definition.

INCI namesh-Polypeptide-4
FunctionAntioxidant · Hair Conditioning
FeedstockProduced by fermenting genetically engineered E. coli that…

How we scored it

Recombinant protein produced by biological fermentation in E. coli from natural amino acids (fermentation products). 100% natural.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli that express a human-identical protein sequence. The resulting protein is a biological fermentation product built entirely from natural amino acids.

In plain English

A protein ingredient made by growing genetically engineered bacteria that produce a human-identical protein through fermentation. Used in skincare for its antioxidant and skin- and hair-conditioning properties.

CosIng definition: sh-Polypeptide-4 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Stem Cell Factor used as such or adapted to the production host. It contains a maximum of 273 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-4