How we scored it
Recombinant protein (155 amino acids) produced in E. coli on a sugar-based medium; built wholly from the 20 standard amino acids, so counted 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Dominant route: recombinant expression of a synthetic human interleukin-17A gene in E. coli, then purification. No alternative route is commercially significant.
In plain English
A copy of the human protein interleukin-17A made by fermentation in E. coli bacteria and used to condition skin. It is built from the 20 standard amino acids.
CosIng definition: sh-Polypeptide-36 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Interleukin 17 Alpha . It contains a maximum of 155 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-36. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-36. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-36