Is sh-Polypeptide-33 natural?

Produced as a recombinant protein by E. coli fermentation of a synthesised copy of the human tumour necrosis factor alpha gene on a nutrient medium typically based on glucose or glycerol, then purified. No commercially significant non-fermentation route exists.

A laboratory-made copy of the human protein tumour necrosis factor alpha. It is produced by E. coli bacteria grown in fermentation tanks from a synthesised copy of the human gene, and is added to products as a skin-conditioning ingredient.

CosIng definition: sh-Polypeptide-33 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Tumor Necrosis Factor Alpha. It contains a maximum of 233 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids