Is sh-Polypeptide-31 natural?

E. coli carrying a synthesised copy of the human Insulin-Like Growth Factor 2 gene is grown in a fermenter on sugar and ammonium-salt media, then the protein is purified. Other expression hosts would not change the value.

A human growth-factor protein (insulin-like growth factor 2) produced by E. coli bacteria grown in a fermenter, using a copy of the human gene. It is listed as a skin-conditioning ingredient and is built entirely from the 20 standard amino acids.

CosIng definition: sh-Polypeptide-31 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Insulin-Like Growth Factor 2. It contains a maximum of 180 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids