How we scored it
Recombinant protein, single amino-acid chain, produced by bacterial fermentation; no non-amino-acid synthetic modification. 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermenting E. coli engineered with a synthesised copy of the human keratinocyte growth factor gene; the bacteria manufacture the protein from ordinary fermentation feedstock. No alternative production route is in commercial use.
In plain English
sh-Polypeptide-3 is a lab-made protein matching a natural human protein (keratinocyte growth factor), produced by fermenting engineered bacteria (E. coli). It's used in skincare as a skin-conditioning ingredient.
CosIng definition: It is a single chain recombinant human peptide, produced by fermentation in E. Coli. The starting gene is a synthesized copy of the human gene which codes for Keratinocyte Growth Factor used as such or adapted to the production host.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-3