Database/Skin Conditioning/sh-Polypeptide-22
100% natural origin · ISO 16128

Is sh-Polypeptide-22 natural?

Yes. All amino acids, and any glycosylation sugars, originate from microbial fermentation with no synthetic fragment retained in the protein.

INCI namesh-Polypeptide-22
FunctionSkin Conditioning
FeedstockProduced by fermenting genetically engineered E. coli expressing…

How we scored it

Recombinant protein built from the 20 standard amino acids, produced by E. coli fermentation; amino acids and any glycosylation sugars are natural, no petrochemical fragments added = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli expressing a protein sequence identical to human TGF-beta-1, then purified. No alternative synthetic chemical route is used commercially at this scale.

In plain English

A lab-made protein, identical in sequence to a natural human signalling protein, produced by fermenting genetically engineered bacteria. Used in skincare for its conditioning effect.

CosIng definition: sh-Polypeptide-22 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Transforming Growth Factor Beta 1. It contains a maximum of 390 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-22. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-22. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-22