How we scored it
Recombinant protein assembled from the 20 standard amino acids via E. coli fermentation; fermentation-built peptides are natural origin.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermentation of genetically engineered E. coli expressing a gene identical to human Interleukin 1 Alpha. Built entirely from the 20 standard, fermentation-derived amino acids.
In plain English
A lab-made protein identical to a human signaling protein, produced by fermenting engineered bacteria. Used in skincare as a skin-conditioning ingredient.
CosIng definition: sh-Polypeptide-17 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Interleukin 1 Alpha. It contains a maximum of 272 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-17. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-17. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-17