Database/Skin Conditioning/sh-Polypeptide-15
100% natural origin · ISO 16128

Is sh-Polypeptide-15 natural?

Yes. Gene-directed fermentation in E. coli assembles standard amino acids into the TIMP-2 sequence; no petrochemical mass enters the final chain.

INCI namesh-Polypeptide-15
FunctionSkin Conditioning
FeedstockProduced by fermentation of genetically engineered E. coli…

How we scored it

Recombinant protein assembled from the 20 standard amino acids via E. coli fermentation; treats fermentation-built peptides as natural origin.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermentation of genetically engineered E. coli expressing a gene identical to human TIMP-2. The protein is built entirely from the 20 standard, fermentation-derived amino acids.

In plain English

A lab-made protein identical to one in human skin, produced by fermenting engineered bacteria. Used in serums and creams as a skin-conditioning ingredient.

CosIng definition: sh-Polypeptide-15 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Tissue Inhibitor of Metalloproteinases-2. It contains a maximum of 220 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-15. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-15. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-15