How we scored it
Recombinant protein from the 20 standard amino acids via bacterial fermentation (Noggin protein copy); synthesis leaves no mass = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermenting genetically modified E. coli expressing a synthetic gene copy of human Noggin protein. No alternative route.
In plain English
A protein made by fermenting engineered bacteria that produce a copy of a natural human protein. Used in skin-protecting formulations.
CosIng definition: sh-Polypeptide-13 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Noggin Protein used as such or adapted to the production host. It contains a maximum of 232 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-13. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-13. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-13