How we scored it
Recombinant protein assembled from the 20 standard amino acids via bacterial fermentation; amino acids are fermentation products, synthesis leaves no mass = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermenting genetically modified E. coli expressing a synthetic gene copy of human Interleukin-4. No alternative production route.
In plain English
A protein ingredient made by fermenting bacteria engineered to produce a copy of a natural human skin-signalling protein. Used to condition skin.
CosIng definition: sh-Polypeptide-12 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Interleukin-4. It contains a maximum of 153 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-POLYPEPTIDE-12. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-POLYPEPTIDE-12. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-12