Database/sh-Polypeptide-11
100% natural origin · ISO 16128

Is sh-Polypeptide-11 natural?

Yes. Amino-acid residues are fermentation-derived, so the assembled recombinant protein is fully natural origin.

INCI namesh-Polypeptide-11
FeedstockProduced by fermenting genetically engineered E. coli synthesizing…

How we scored it

Recombinant peptide up to 155 residues (FGF1 analog); amino acids from E. coli fermentation are natural = 1.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli synthesizing a human growth-factor analog from natural amino acids. No petrochemical mass remains in the product.

In plain English

A lab-made copy of a human growth-factor protein, produced by fermenting genetically modified bacteria. Used in skin care products for skin-conditioning effects.

CosIng definition: sh-Polypeptide-11 is a single chain recombinant human peptide, produced by fermentation in E. Coli. The starting gene is a synthesized copy of the human gene which codes for Acidic Fibroblast Growth Factor 1 used as such or adapted to the production host. It contains a maximum of 155 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-11. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-11. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-11