Database/Skin Protecting/sh-Polypeptide-103
100% natural origin · ISO 16128

Is sh-Polypeptide-103 natural?

Yes. Recombinant heat-shock-protein-beta-2 sequence assembled from fermentation-derived amino acids in engineered E. coli; production machinery leaves no mass in product.

INCI namesh-Polypeptide-103
FunctionSkin Protecting
FeedstockProduced by fermenting genetically engineered E. coli expressing…

How we scored it

Peptide/protein built from standard amino acids via fermentation = 1.0, independent of chain length (182 residues).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli expressing a human-heat-shock-protein-beta-2-identical sequence built from standard amino acids. No petrochemical alternative route is used commercially.

In plain English

A lab-made copy of a human heat-shock protein, produced by fermenting engineered bacteria. Used to help protect and condition skin.

CosIng definition: sh-Polypeptide-103 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Heat shock protein beta-2, used as such or adapted to the production host. It contains a maximum of 182 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-103. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-103. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-103