Database/Skin Conditioning/sh-Polypeptide-1
100% natural origin · ISO 16128

Is sh-Polypeptide-1 natural?

Yes. Proteins built solely from standard amino acids by fermentation are natural origin, regardless of chain length.

INCI namesh-Polypeptide-1
FunctionSkin Conditioning
FeedstockProduced by fermenting genetically modified E. coli expressing…

How we scored it

All atoms trace to the 20 standard amino acids assembled by E. coli fermentation; disulfide bonds/glycosylation add only natural atoms → 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically modified E. coli expressing the human Basic Fibroblast Growth Factor gene; purified from the broth. No petrochemical atoms are introduced.

In plain English

A lab-made copy of human Basic Fibroblast Growth Factor, produced by fermenting genetically modified bacteria that build the protein from standard amino acids. Used for skin conditioning.

CosIng definition: sh-Polypeptide-1 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Basic Fibroblast Growth Factor used as such or adapted to the production host. It contains a maximum of 288 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-POLYPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-POLYPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-POLYPEPTIDE-1