How we scored it
Arg-Lys-Asp-Val-Tyr, C30H49N9O9 679.8 Da, free termini, no caps; all residues are amino acids (natural, fermentation); 679.8 / 679.8 = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Amino acids from sugar fermentation or protein hydrolysates are coupled by solid-phase or solution peptide synthesis into the pentapeptide. No alternative route is significant.
In plain English
A short chain of five amino acids (arginine, lysine, aspartic acid, valine, tyrosine) used as a skin-conditioning ingredient. It is assembled in a lab from individual amino acids, which are normally made by fermenting sugar.
CosIng definition: sh-pentapeptide-1 is the synthetic peptide containing arginine, aspartic acid, lysine, tyrosine and valine residues
Structure
(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2sh-Pentapeptide-1. PubChem CID 451417. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
- 3SH-PENTAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 4SH-PENTAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-PENTAPEPTIDE-1