Database/Humectant/sh-Oligopeptide-9
100% natural origin · ISO 16128

Is sh-Oligopeptide-9 natural?

Yes. Fermentation-derived, amino-acid peptide is natural origin.

INCI namesh-Oligopeptide-9
FunctionHumectant · Skin Conditioning
FeedstockProduced by fermenting engineered E. coli expressing a…

How we scored it

11-amino-acid recombinant peptide from standard amino acids via fermentation; no petrochemical mass added.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting engineered E. coli expressing a gene based on human enkephalin, assembled from standard amino acids. No alternative commercial route.

In plain English

A lab-made peptide modeled on a natural skin-signalling protein, produced by fermenting engineered bacteria. Helps skin hold moisture, feel conditioned, and stay protected.

CosIng definition: sh-Oligopeptide-9 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Enkephalin which contains a maximum of 267 amino acids. This protein contains 11 amino acids consisting of arginine, glutamic acid, glutamine, glycine, leucine, methionine, phenylalanine, and tyrosine and may contain disulfide bonds and/or sugar. The protein consists of the proper sequence of the 20 standard amino acids

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-OLIGOPEPTIDE-9. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-OLIGOPEPTIDE-9. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-OLIGOPEPTIDE-9