Database/Skin Conditioning/sh-Oligopeptide-6
100% natural origin · ISO 16128

Is sh-Oligopeptide-6 natural?

Yes. All amino-acid residues are fermentation-derived building blocks, so the assembled peptide is fully natural origin.

INCI namesh-Oligopeptide-6
CAS61512-76-3
FormulaC77H120N18O26S · 1745.9 Da
FunctionSkin Conditioning
FeedstockProduced by fermenting genetically engineered E. coli that…

How we scored it

16-residue recombinant peptide; amino acids from E. coli fermentation are natural building blocks = 1.0
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by fermenting genetically engineered E. coli that synthesize the peptide from natural amino acids. No petrochemical mass remains in the final protein.

In plain English

A lab-made copy of a small human protein fragment, produced by fermenting genetically modified bacteria. Used in skin care products for its conditioning effect on skin.

CosIng definition: sh-Oligopeptide-6 is a single chain recombinant human peptide, produced by fermentation in E. coli and contains 16 amino acids. The starting gene is synthesized to be identical to the human gene which codes for Alpha Endorphin and codes for a total of 267 amino acids. This protein contains 16 amino acids which may contain disulfide bonds and/or sugar. The protein consists of the proper sequence of the 20 standard amino acids

Structure

2D structure of sh-Oligopeptide-6

(4S)-5-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid

PubChem CID 16138308 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2sh-Oligopeptide-6. PubChem CID 16138308. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3SH-OLIGOPEPTIDE-6. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4SH-OLIGOPEPTIDE-6. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-OLIGOPEPTIDE-6