How we scored it
Recombinant 41-amino-acid peptide from the 20 standard amino acids via fermentation; no petrochemical mass.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.
Where it comes from
Produced by fermenting E. coli engineered with a synthetic copy of the human AIMP1 gene; amino acids are the sole feedstock. No alternative commercial route exists.
In plain English
A lab-made peptide produced by fermenting engineered bacteria carrying a copy of a human gene. Used in skincare as a skin-conditioning ingredient.
CosIng definition: sh-Oligopeptide-5 is a single chain recombinant human peptide, produced by fermentation in E. coli and contains 41 amino acids. . The starting gene is an exact copy for the human gene which codes for ARS Interacting Multi-Functional Protein 1, and codes for a total of 312 amino acids which may contain disulfide bonds and/or sugar. The protein consists of the proper sequence of the 20 standard amino acids
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-OLIGOPEPTIDE-5. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-OLIGOPEPTIDE-5. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-OLIGOPEPTIDE-5