How we scored it
Where it comes from
Fermentation-derived or hydrolysate amino acids are assembled by solid-phase peptide synthesis to match a segment of human Klotho, and reagents leave no mass. No alternative route is commercially significant.
In plain English
A nine-amino-acid peptide made in a laboratory to match part of a human protein called Klotho. It is listed as a skin-conditioning ingredient. It is built from amino acids, which are generally obtained by fermentation or by breaking down proteins.
CosIng definition: sh-Nonapeptide-4 is a single chain human peptide produced synthetically to be identical to a portion of the protein, Klotho, and contains 9 amino acids consisting of aspartic acid, cysteine, glycine, isoleucine, proline, serine and tyrosine. Klotho contains a maximum of 1012 amino acids consisting of the proper sequence of the 20 standard amino acids.
References
- 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
- 2SH-NONAPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
- 3SH-NONAPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-NONAPEPTIDE-4