Database/Skin Conditioning/sh-Nonapeptide-4
100% natural origin · ISO 16128

Is sh-Nonapeptide-4 natural?

Yes. Aspartic acid, cysteine, glycine, isoleucine, proline, serine and tyrosine are fermentation or protein-hydrolysate amino acids; synthesis reagents and protecting groups leave no mass.

INCI namesh-Nonapeptide-4
FunctionSkin Conditioning
FeedstockFermentation-derived or hydrolysate amino acids are assembled by…

How we scored it

9 amino-acid residues (Asp, Cys, Gly, Ile, Pro, Ser, Tyr), all natural building blocks; no acyl or other cap described: 1.00.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Fermentation-derived or hydrolysate amino acids are assembled by solid-phase peptide synthesis to match a segment of human Klotho, and reagents leave no mass. No alternative route is commercially significant.

In plain English

A nine-amino-acid peptide made in a laboratory to match part of a human protein called Klotho. It is listed as a skin-conditioning ingredient. It is built from amino acids, which are generally obtained by fermentation or by breaking down proteins.

CosIng definition: sh-Nonapeptide-4 is a single chain human peptide produced synthetically to be identical to a portion of the protein, Klotho, and contains 9 amino acids consisting of aspartic acid, cysteine, glycine, isoleucine, proline, serine and tyrosine. Klotho contains a maximum of 1012 amino acids consisting of the proper sequence of the 20 standard amino acids.

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2SH-NONAPEPTIDE-4. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3SH-NONAPEPTIDE-4. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=SH-NONAPEPTIDE-4